Vandetanib

What it is used for

CAPRELSA in patients with indolent, asymptomatic or slowly progressing disease only after careful consideration of the treatment related risks of CAPRELSA.

Side effects, and when to stop

The following serious adverse reactions are discussed elsewhere in the label:

• QT Prolongation and Torsades de Pointes
• Severe Skin Reactions
• Interstitial Lung Disease
• Ischemic Cerebrovascular Events
• Hemorrhage
• Heart Failure
• Diarrhea
• Hypothyroidism
• Hypertension
• Reversible Posterior Leukoencephalopathy Syndrome
• Renal Failure
• Embryo-Fetal Toxicity
• Osteonecrosis

Who should not take it

Do not use in patients with congenital long QT syndrome.

Storing it

CAPRELSA tablets should be stored at room temperature between 68°F and 77°F (20°C and 25°C); excursions permitted to 59°F–86°F (15°C-30°C).

Procedures for proper handling and disposal of anticancer drugs should be considered. A guideline on this subject has been published. 1 Do not crush CAPRELSA tablets.

2 dosage and administration

The recommended dose of CAPRELSA is 300 mg taken orally once daily until disease progression or unacceptable toxicity occurs.

CAPRELSA may be taken with or without food.

Do not take a missed dose within 12 hours of the next dose.

Do not crush CAPRELSA tablets. The tablets can be dispersed in 2 ounces of water by stirring for approximately 10 minutes (will not completely dissolve). Do not use other liquids for dispersion. Swallow immediately after dispersion. Mix any remaining residue with 4 additional ounces of water and swallow.

The dispersion can also be administered through nasogastric or gastrostomy tubes.