Pitavastatin

What it is used for

Pitavastatin tablets are indicated as an adjunct to diet to reduce low-density lipoprotein cholesterol (LDL-C) in:

• Adults with primary hyperlipidemia.
• Adults and pediatric patients aged 8 years and older with heterozygous familial hypercholesterolemia (HeFH).

Side effects, and when to stop

The following serious adverse reactions are discussed in other sections of the labeling:

• Myopathy and Rhabdomyolysis
• Immune-Mediated Necrotizing Myopathy
• Hepatic Dysfunction
• Increases in HbA1c and Fasting Serum Glucose Levels

Who should not take it

Pitavastatin tablets are contraindicated in the following conditions:

• Concomitant use of cyclosporine.
• Acute liver failure or decompensated cirrhosis.
• Hypersensitivity to pitavastatin or any excipients in pitavastatin tablets. Hypersensitivity reactions including angioedema, rash, pruritus, and urticaria have been reported with pitavastatin tablets.

Other medicines and interactions

Table 2 includes a list of drugs that increase the risk of myopathy and rhabdomyolysis when administered concomitantly with pitavastatin tablets and instructions for preventing or managing drug interactions.