Oxymorphone

What it is used for

Limitations of Use:

• Because of the risks of addiction, abuse, misuse, overdose, and death, which can occur at any dosage or duration and persist over the course of therapy, reserve opioid analgesics, including oxymorphone hydrochloride tablets for use in patients for whom alternative treatment options are ineffective, not tolerated, or would be otherwise inadequate to provide sufficient management of pain.

Side effects, and when to stop

The following serious adverse reactions are described, or described in greater detail, in other sections:

• Addiction, Abuse, and Misuse
• Life-Threatening Respiratory Depression
• Interactions with Benzodiazepines and Other CNS Depressants
• Neonatal Opioid Withdrawal Syndrome
• Opioid-induced Hyperalgesia and Allodynia
• Anaphylaxis, Angioedema, and Other Hypersensitivity Reactions
• Adrenal Insufficiency
• Severe Hypotension
• Gastrointestinal Adverse Reactions
• Seizures
• Withdrawal

Who should not take it

Oxymorphone hydrochloride is contraindicated in patients with:

• Significant respiratory depression
• Acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment
• Known or suspected gastrointestinal obstruction, including paralytic ileus
• Hypersensitivity to oxymorphone (e.g., anaphylaxis, angioedema) or
• Moderate or severe hepatic impairment.

Other medicines and interactions

Table 2 includes clinically significant drug interactions with oxymorphone hydrochloride.

Table 2: Clinically Significant Drug Interactions with Oxymorphone Hydrochloride