Lactate

What it is used for

Lactated Ringer’s and Dextrose (5%) Injection is indicated for use as a source of water, electrolytes, and calories or as an alkalinizing agent in adults and pediatric patients.

Side effects, and when to stop

The following serious adverse reactions are discussed in greater detail in other sections of the labeling:

• Serious Risk with Concomitant Use with Ceftriaxone
• Air Embolism
• Hypersensitivity Reactions
• Potassium Imbalances
• Hyponatremia
• Neonatal Hypoglycemia
• Hyperglycemia and Hyperosmolar Hyperglycemic State
• Hypercalcemia
• Fluid Overload
• Acid/Base Imbalances

The following adverse reactions have been identified during post approval use of Lactated Ringer’s products. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure:

• General Disorders and Administration Site Conditions:
• Phlebitis, extravasation, infusion site inflammation, infusion site swelling, infusion site rash, infusion site pruritus, infusion site erythema, infusion site pain, infusion site burning and infusion site hypoaesthesia.
• Hypersensitivity Reactions and Infusion Reactions:
• Angioedema, chest pain/discomfort, bradycardia or tachycardia, hypotension, respiratory distress, bronchospasm, dyspnea, cough, urticaria, rash, pruritus, erythema, flushing, throat irritation, paresthesia, oral hypoesthesia, dysgeusia, nausea, anxiety, pyrexia, and headache, laryngeal edema, sneezing, and injection site infection.
• Metabolism and Nutrition Disorders:
• Hyperkalemia, hyponatremia, and hypervolemia.
• Nervous System Disorders:
• Hyponatremic encephalopathy.

Who should not take it

Lactated Ringer’s and Dextrose (5%) Injection is contraindicated in:

• Neonates (28 days of age or younger) who are receiving concomitant treatment with ceftriaxone, even if separate infusion lines are used, due to the risk of fatal ceftriaxone-calcium salt precipitation in the neonate’s bloodstream.
• Patients with known hypersensitivity to any of the components of Lactated Ringer’s and Dextrose (5%) Injection.
• Patients with clinically significant hyperglycemia.