Labetalol

What it is used for

Labetalol HCl Injection is indicated in severe hypertension, to lower blood pressure.

Side effects, and when to stop

The following clinically significant adverse reactions are described elsewhere in the labeling:

• Hypotension
• Bradycardia
• Depression of myocardial contractility in patients with overt congestive heart failure
• Aggravation of angina
• Significant decline in cardiac output following coronary bypass
• Bronchospasm in patients with reactive airway disease
• Paradoxical hypertensive responses in patients with pheochromocytoma
• Hepatic injury
• Acute hypersensitivity reaction

Who should not take it

Labetalol Hydrochloride Injection is contraindicated in patients with:

• Bronchial asthma or obstructive airway disease.
• Severe sinus bradycardia:
• Heart block greater than first degree.
• Cardiogenic shock.
• IV administration of non-dihydropyridine calcium-channel antagonists (e.g., verapamil)
• Hypersensitivity reactions, including anaphylaxis, to labetalol

Storing it

Store at 20°C to 25°C (68°F to 77°F) with excursions permitted between 15°C to 30° C (59°F to 86° F). DO NOT FREEZE. PROTECT FROM LIGHT.

Labetalol HCl in Sodium Chloride Injection and Labetalol HCl in Dextrose Injection: Do not remove from overwrap until ready to use.

Labetalol Hydrochloride Injection, USP, prefilled syringe and vial: Retain in carton until time of use.