Cyclophosphamide

What it is used for

Malignant Diseases

FRINDOVYX is indicated for the treatment of adult and pediatric patients with:

• malignant lymphomas (Stages III and IV of the Ann Arbor staging system), Hodgkin's disease, lymphocytic lymphoma (nodular or diffuse), mixed-cell type lymphoma, histiocytic lymphoma Burkitt's lymphoma
• multiple myeloma
• leukemias: chronic lymphocytic leukemia, chronic granulocytic leukemia (it is usually ineffective in acute blastic crisis), acute myelogenous and monocytic leukemia, acute lymphoblastic (stem-cell) leukemia (cyclophosphamide given during remission is effective in prolonging its duration)
• mycosis fungoides (advanced disease)
• neuroblastoma (disseminated disease)
• adenocarcinoma of the ovary
• retinoblastoma
• carcinoma of the breast

Cyclophosphamide, although effective alone in susceptible malignancies, is more frequently used concurrently or sequentially with other antineoplastic drugs.

Side effects, and when to stop

The following adverse reactions are discussed in more detail in other sections of the labeling.

• Hypersensitivity
• Myelosuppression, Immunosuppression, Bone Marrow Failure, and Infections
• Urinary Tract and Renal Toxicity
• Cardiotoxicity
• Pulmonary Toxicity
• Secondary Malignancies
• Veno-occlusive Liver Disease
• Alcohol Content
• Infertility
• Impaired Wound Healing
• Hyponatremia

Who should not take it

Hypersensitivity

FRINDOVYX is contraindicated in patients who have a history of severe hypersensitivity reactions to cyclophosphamide, any of its metabolites, or to other components of the product. Anaphylactic reactions including death have been reported with cyclophosphamide. Cross-sensitivity with other alkylating agents can occur.

Urinary Outflow Obstruction

FRINDOVYX is contraindicated in patients with urinary outflow obstruction.