Busulfan

What it is used for

BUSULFEX is indicated for use in combination with cyclophosphamide as a conditioning regimen prior to allogeneic hematopoietic progenitor cell transplantation for chronic myelogenous leukemia.

Side effects, and when to stop

The following adverse reactions are discussed in more detail in other sections of the labeling:

• Myelosuppression
• Seizures
• Hepatic Veno-Occlusive Disease (HVOD)
• Embryo-fetal Toxicity
• Cardiac Tamponade
• Bronchopulmonary Dysplasia
• Cellular Dysplasia

Who should not take it

BUSULFEX is contraindicated in patients with a history of hypersensitivity to any of its components.

Storing it

Unopened vials of BUSULFEX must be stored under refrigerated conditions between 2°C to 8°C (36°F to 46°F). Discard unused portion.

BUSULFEX diluted in 0.9% Sodium Chloride Injection, USP, or 5% Dextrose Injection, USP, is stable at room temperature (25°C) for up to 8 hours, but the infusion must be completed within that time.

BUSULFEX diluted in 0.9% Sodium Chloride Injection, USP, is stable at refrigerated conditions (2°C to 8°C) for up to 12 hours but the infusion must be completed within that time.

BUSULFEX is a cytotoxic drug. Follow applicable special handling and disposal procedures 1.