Xanomeline

COBENFY is indicated for the treatment of schizophrenia in adults.

Prescribing label

Selected manufacturer label information, organised into consistent sections by Sofidex. This source is written for healthcare professionals; ask your pharmacist to explain instructions that are unclear. Read the full label at DailyMed ↗

Drug facts

Used for: COBENFY is indicated for the treatment of schizophrenia in adults.
Do not take if: urinary retention.
moderate (Child-Pugh Class B) or severe (Child-Pugh Class C) hepatic impairment.
gastric retention.
history of hypersensitivity to COBENFY or trospium chloride. Angioedema has been reported with COBENFY and trospium chloride.

Side effects, and when to stop

The following clinically significant adverse reactions are described elsewhere in the labeling:

Risk of Urinary Retention
Risk of Use in Patients with Hepatic Impairment
Risk of Use in Patients with Biliary Disease
Decreased Gastrointestinal Motility
Risk of Angioedema
Risk of Use in Patients with Narrow-angle Glaucoma
Increases in Heart Rate
Anticholinergic Adverse Reactions in Patients with Renal Impairment
Central Nervous System Effects

Who should not take it

COBENFY is contraindicated in patients with:

urinary retention.
moderate (Child-Pugh Class B) or severe (Child-Pugh Class C) hepatic impairment.
gastric retention.
history of hypersensitivity to COBENFY or trospium chloride. Angioedema has been reported with COBENFY and trospium chloride.
untreated narrow-angle glaucoma.

Cite this page

NLM: sofidex [Internet]. Daloreum; c2026. Xanomeline; [reviewed 2026 Aug 3; cited 2026 Nov 10]. Available from: https://sofidex.com/patients/medicines/xanomeline
APA 7th: sofidex. (2026, August 3). Xanomeline. Daloreum. Retrieved November 10, 2026, from https://sofidex.com/patients/medicines/xanomeline
AMA 11th: Xanomeline. sofidex. Reviewed August 3, 2026. Accessed November 10, 2026. https://sofidex.com/patients/medicines/xanomeline

The cited date is today’s, because a citation records when you read the page. The reviewed date is when a clinician last checked it.