Thrombin

What it is used for

EVITHROM™ Thrombin, Topical (Human), is indicated as an aid to hemostasis whenever oozing blood and minor bleeding from capillaries and small venules is accessible and control of bleeding by standard surgical techniques (such as suture, ligature or cautery) is ineffective or impractical.

EVITHROM™ Thrombin, Topical (Human), may be used in conjunction with an Absorbable Gelatin Sponge, USP.

Side effects, and when to stop

The most common adverse reactions during clinical trial (reported in at least 2% of subjects treated with EVITHROM™) were prolonged activated partial thromboplastin time, increased INR, decreased lymphocyte count, prolonged prothrombin time and increased neutrophil count.

Who should not take it

• Do not use in individuals known to have an anaphylactic or severe systemic reaction to EVITHROM™ or to human blood products.
• Do not use for the treatment of severe or brisk arterial bleeding.

Storing it

• Store EVITHROM™ powder vials at 2- 25°C (36-77°F) for up to 2 years.
• Discard if the packaging of EVITHROM™ is damaged.
• Keep the vials protected from light.
• Store reconstituted EVITHROM™ solution at room temperature for up to 8 hours.
• Do not freeze or refrigerate EVITHROM™ once it has been reconstituted.
• Discard unused contents.