Pyridostigmine

What it is used for

Pyridostigmine bromide is indicated for pretreatment against the lethal effects of soman nerve agent poisoning in adults. Pyridostigmine bromide is intended for use in conjunction with protective garments, including a mask. At the first sign of nerve agent poisoning, pyridostigmine bromide should be stopped, and atropine and pralidoxime therapy started immediately.

The evidence for the effectiveness of pyridostigmine bromide as pretreatment against soman-induced toxicity was derived from animal studies alone.

FOR MILITARY MEDICAL USE ONLY

Side effects, and when to stop

The following serious adverse reactions are discussed elsewhere in the labeling:

• Risk of Improper Use of Pyridostigmine Bromide
• Individuals at Increased Risk of Anticholinergic Adverse Reactions
• Use in Bromide-Sensitive Individuals
• Serious Adverse Reactions, Such as Difficulty Breathing, Severe Dizziness, Loss of Consciousness

Who should not take it

Pyridostigmine bromide is contraindicated in patients with:

• Mechanical intestinal or urinary obstruction
• Known hypersensitivity to pyridostigmine or other anticholinesterase agents

Storing it

Store refrigerated between 2°C to 8°C (36°F to 46°F) in carton or foil overwrap to protect from light until the expiration date. Once removed from refrigerator, store at 20°C to 25°C (68°F to 77°F) in carton or foil overwrap for up to 5 years minus half of the time spent under refrigerated storage or until the expiration date, whichever comes first. Following removal of the blister packages from the foil overwrap, discard the contents of the blister package after 14 months or after the expiration date, whichever comes first.