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Meds & supplements  ›  Opicapone

Medicine · Catechol-O-Methyltransferase Inhibitor

Opicapone

ONGENTYS is indicated as adjunctive treatment to levodopa/carbidopa in patients with Parkinson’s disease (PD) experiencing “off” episodes.

Prescribing label

Selected manufacturer label information, organised into consistent sections by Sofidex. This source is written for healthcare professionals; ask your pharmacist to explain instructions that are unclear. Read the full label at DailyMed ↗

Drug facts

Used for
ONGENTYS is indicated as adjunctive treatment to levodopa/carbidopa in patients with Parkinson’s disease (PD) experiencing “off” episodes.
Do not take if
  • Concomitant use of non-selective monoamine oxidase (MAO) inhibitors [ see Drug Interactions ( 7.1 ) ].
  • Pheochromocytoma, paraganglioma, or other catecholamine secreting neoplasms.

Side effects, and when to stop

The following clinically significant adverse reactions are discussed in more detail in other sections of the labeling:

  • Cardiovascular Effects with Concomitant Use of Drugs Metabolized by Catechol-O-Methyltransferase (COMT)
  • Falling Asleep During Activities of Daily Living and Somnolence
  • Hypotension/Syncope
  • Dyskinesia
  • Hallucinations and Psychosis
  • Impulse Control/Compulsive Disorders
  • Withdrawal-Emergent Hyperpyrexia and Confusion

Who should not take it

ONGENTYS is contraindicated in patients with:

  • Concomitant use of non-selective monoamine oxidase (MAO) inhibitors [ see Drug Interactions ( 7.1 ) ].
  • Pheochromocytoma, paraganglioma, or other catecholamine secreting neoplasms.

Storing it

Store at a temperature below 30°C (86°F).

Cite this page

NLM

sofidex [Internet]. Daloreum; c2026. Opicapone; [reviewed 2026 Aug 3; cited 2026 Nov 10]. Available from: https://sofidex.com/patients/medicines/opicapone

APA 7th

sofidex. (2026, August 3). Opicapone. Daloreum. Retrieved November 10, 2026, from https://sofidex.com/patients/medicines/opicapone

AMA 11th

Opicapone. sofidex. Reviewed August 3, 2026. Accessed November 10, 2026. https://sofidex.com/patients/medicines/opicapone

The cited date is today’s, because a citation records when you read the page. The reviewed date is when a clinician last checked it.