Niraparib

What it is used for

AKEEGA with prednisone is indicated for the treatment of adult patients with deleterious or suspected deleterious BRCA -mutated ( BRCA m) metastatic castration-resistant prostate cancer (mCRPC).

Select patients for therapy based on an FDA-approved test for AKEEGA.

Side effects, and when to stop

The following adverse reactions are discussed elsewhere in the labeling:

• Myelodysplastic syndrome/acute myeloid leukemia
• Myelosuppression
• Hypokalemia, fluid retention, and cardiovascular adverse reactions
• Hepatotoxicity
• Adrenocortical insufficiency
• Hypoglycemia
• Increased fractures and mortality in combination with Radium 223 Dichloride
• Posterior reversible encephalopathy syndrome

Who should not take it

None.

Storing it

Storage and Handling

Store at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F).

Based on its mechanism of action, AKEEGA may harm a developing fetus. Females who are or may become pregnant should handle AKEEGA tablets with protection, e.g., gloves.