Meds & supplements › Levoleucovorin
Medicine
Levoleucovorin
Levoleucovorin Injection is indicated for: rescue after high-dose methotrexate therapy in adult and pediatric patients with osteosarcoma.
Selected manufacturer label information, organised into consistent sections by Sofidex. This source is written for healthcare professionals; ask your pharmacist to explain instructions that are unclear. Read the full label at DailyMed ↗
Drug facts
- Used for
- rescue after high-dose methotrexate therapy in adult and pediatric patients with osteosarcoma.
- diminishing the toxicity associated with overdosage of folic acid antagonists or impaired methotrexate elimination in adult and pediatric patients.
- the treatment of adults with metastatic colorectal cancer in combination with fluorouracil.
- Do not take if
- Levoleucovorin injection is contraindicated in patients who have had severe hypersensitivity to leucovorin products, folic acid or folinic acid.
What it is used for
Levoleucovorin injection is indicated for:
- rescue after high-dose methotrexate therapy in adult and pediatric patients with osteosarcoma.
- diminishing the toxicity associated with overdosage of folic acid antagonists or impaired methotrexate elimination in adult and pediatric patients.
- the treatment of adults with metastatic colorectal cancer in combination with fluorouracil.
Limitations of Use
Levoleucovorin injection is not indicated for pernicious anemia and megaloblastic anemia secondary to the lack of vitamin B 12, because of the risk of progression of neurologic manifestations despite hematologic remission.
Side effects, and when to stop
The following clinically significant adverse reactions are described elsewhere in the labeling:
- Hypercalcemia
- Increased gastrointestinal toxicities with fluorouracil
Who should not take it
Levoleucovorin injection is contraindicated in patients who have had severe hypersensitivity to leucovorin products, folic acid or folinic acid.
Cite this page
- NLM
sofidex [Internet]. Daloreum; c2026. Levoleucovorin; [reviewed 2026 Aug 3; cited 2026 Nov 10]. Available from: https://sofidex.com/patients/medicines/levoleucovorin
- APA 7th
sofidex. (2026, August 3). Levoleucovorin. Daloreum. Retrieved November 10, 2026, from https://sofidex.com/patients/medicines/levoleucovorin
- AMA 11th
Levoleucovorin. sofidex. Reviewed August 3, 2026. Accessed November 10, 2026. https://sofidex.com/patients/medicines/levoleucovorin
The cited date is today’s, because a citation records when you read the page. The reviewed date is when a clinician last checked it.