Glyburide

What it is used for

Glyburide and metformin hydrochloride tablets are indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Side effects, and when to stop

The following adverse reactions are also discussed elsewhere in the labeling:

• Lactic Acidosis
• Hypoglycemia
• Cardiovascular mortality
• Hemolytic anemia
• Vitamin B 12 Deficiency [ see Warnings and Precautions ( 5.5 ) ]

Who should not take it

Glyburide and metformin hydrochloride tablets are contraindicated in patients with:

• Severe renal impairment (eGFR below 30 mL/min/1.73 m 2 ).
• Hypersensitivity to metformin or glyburide.
• Acute or chronic metabolic acidosis, including diabetic ketoacidosis, with or without coma.
• Concomitant administration of bosentan.

Other medicines and interactions

Table 3 presents clinically significant drug interactions with glyburide and metformin hydrochloride.