Flurbiprofen

What it is used for

Flurbiprofen tablets are indicated:

• For relief of the signs and symptoms of rheumatoid arthritis.
• For relief of the signs and symptoms of osteoarthritis.

Side effects, and when to stop

The following adverse reactions are discussed in greater detail in other sections of the labeling:

• Cardiovascular Thrombotic Events [ see Warnings and Precautions ]
• GI Bleeding, Ulceration and Perforation [ see Warnings and Precautions ]
• Hepatotoxicity [ see Warnings and Precautions ]
• Hypertension [ see Warnings and Precautions ]
• Heart Failure and Edema [ see Warnings and Precautions ]
• Renal Toxicity and Hyperkalemia [ see Warnings and Precautions ]
• Anaphylactic Reactions [ see Warnings and Precautions ]
• Serious Skin Reactions [ see Warnings and Precautions ]
• Hematologic Toxicity [ see Warnings and Precautions ]

Who should not take it

Flurbiprofen tablets are contraindicated in the following patients:

• Known hypersensitivity (e.g., anaphylactic reactions and serious skin reactions) to flurbiprofen or any components of the drug product [ see Warnings and Precautions (5.7, 5.9) ]
• History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs. Severe, sometimes fatal, anaphylactic reactions to nonsteroidal anti-inflammatory drugs have been reported in such patients [ see Warnings and Precautions (5.7, 5.8) ].
• In the setting of coronary artery bypass graft (CABG) surgery [ see Warnings and Precautions ].

Other medicines and interactions

See Table 1 for clinically significant drug interactions with flurbiprofen.

Storing it

Store at 20° to 25°C (68° to 77°F).

Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).

2 dosage and administration

Carefully consider the potential benefits and risks of flurbiprofen tablets and other treatment options before deciding to use flurbiprofen tablets. Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals [ see Warnings and Precautions (5) ].

After observing the response to initial therapy with flurbiprofen tablets, the dose and frequency should be adjusted to suit an individual patient's needs.

For relief of the signs and symptoms of rheumatoid arthritis or osteoarthritis, the dosage is 200 to 300 mg per day, divided for administration two, three, or four times a day. The largest recommended single dose in a multiple-dose daily regimen is 100 mg.