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Meds & supplements  ›  Diphenhydramine

Medicine

Diphenhydramine

Uses temporarily relieves these symptoms due to hay fever or other respiratory allergies: ■ sneezing ■ itching of the nose or throat ■ runny nose ■ itchy watery eyes ■temporarily relieves these symptoms due to the common cold: ■ sneezing ■…

Drug FactsLabel updated 2026-05-27

Selected manufacturer label information, organised into consistent sections by Sofidex. Read the full label at DailyMed ↗

Drug facts

Used for
  • temporarily relieves these symptoms due to hay fever or other upper respiratory allergies:
  • runny nose
  • sneezing
How to take it
  • Use as directed per healthcare professional.
  • take every 4 to 6 hours, or as directed by a doctor
  • do not take more than 6 doses in 24 hours
Do not take if
  • to make a child sleepy
  • with any other product containing diphenhydramine, even one used on skin

What it is used for

  • temporarily relieves these symptoms due to hay fever or other upper respiratory allergies:
    • runny nose
    • sneezing
    • itchy, watery eyes
    • itching of nose
  • temporarily relieves these symptoms due to the common cold:
    • runny nose
    • sneezing

How to take it

  • Use as directed per healthcare professional.
  • take every 4 to 6 hours, or as directed by a doctor
  • do not take more than 6 doses in 24 hours

While you are taking it

  • marked drowsiness may occur
  • avoid alcoholic drinks
  • alcohol, sedatives, and tranquilizers may increase drowsiness
  • be careful when driving a motor vehicle or operating machinery
  • excitability may occur, especially in children

Who should not take it

  • to make a child sleepy
  • with any other product containing diphenhydramine, even one used on skin

What to say before you start

Ask a doctor or pharmacist before use if you are taking sedatives or tranquilizers

If you are pregnant or breastfeeding

If pregnant or breast-feeding, ask a health professional before use.

Keeping it away from children

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away (1-800-222-1222).

Active ingredient (in each tablet)

Diphenhydramine 25 mg

Other information

  • each tablet contains: calcium 20 mg
  • store at 20-25°C (68-77°F).
  • Avoid high humidity. Protect from light
  • small tablet size, easy to swallow

Cite this page

NLM

sofidex [Internet]. Daloreum; c2026. Diphenhydramine; [reviewed 2026 Aug 2; cited 2026 Nov 10]. Available from: https://sofidex.com/patients/medicines/diphenhydramine

APA 7th

sofidex. (2026, August 2). Diphenhydramine. Daloreum. Retrieved November 10, 2026, from https://sofidex.com/patients/medicines/diphenhydramine

AMA 11th

Diphenhydramine. sofidex. Reviewed August 2, 2026. Accessed November 10, 2026. https://sofidex.com/patients/medicines/diphenhydramine

The cited date is today’s, because a citation records when you read the page. The reviewed date is when a clinician last checked it.