Brimonidine

What it is used for

Brimonidine Tartrate/Timolol Maleate Ophthalmic Solution, 0.2%/0.5% is indicated for the reduction of elevated intraocular pressure (IOP) in patients with glaucoma or ocular hypertension who require adjunctive or replacement therapy due to inadequately controlled IOP.

The IOP-lowering of brimonidine tartrate/timolol maleate ophthalmic solution dosed twice a day was slightly less than that seen with the concomitant administration of 0.5% timolol maleate ophthalmic solution dosed twice a day and 0.2% brimonidine tartrate ophthalmic solution dosed three times per day.

Side effects, and when to stop

The following serious adverse reactions are described elsewhere in the labeling:

• Hypersensitivity Reactions
• Potential for Severe Respiratory or Cardiac Reactions
• Cardiac Failure
• Potentiation of Vascular Insufficiency
• Increased Reactivity to Allergens
• Potentiation of Muscle Weakness
• Masking of Hypoglycemic Symptoms in Patients with Diabetes Mellitus
• Masking of Thyrotoxicosis
• Ocular Hypersensitivity
• Contamination of Topical Ophthalmic Products after Use
• Impairment of Beta-adrenergically Mediated Reflexes During Surgery

2 dosage and administration

The recommended dosage is one drop in the affected eye(s) twice daily approximately 12 hours apart. If more than one topical ophthalmic product is to be used, the different products should be instilled at least 5 minutes apart.