Alirocumab

What it is used for

PRALUENT ® is indicated:

• To reduce the risk of major adverse cardiovascular (CV) events (coronary heart disease death, myocardial infarction, stroke, or unstable angina requiring hospitalization) in adults at increased risk for these events.
• As an adjunct to diet and exercise to reduce low- density lipoprotein cholesterol (LDL-C) in:
  • adults with hypercholesterolemia.
  • adults and pediatric patients aged 8 years and older with heterozygous familial hypercholesterolemia (HeFH).
  • adults with homozygous familial hypercholesterolemia (HoFH).

Side effects, and when to stop

The following adverse reactions are also discussed in the other sections of the labeling:

• Hypersensitivity Reactions

Who should not take it

PRALUENT is contraindicated in patients with a history of a serious hypersensitivity reaction to alirocumab or any of the excipients in PRALUENT. Hypersensitivity vasculitis, angioedema, and hypersensitivity reactions requiring hospitalization have occurred.

Storing it

Store in a refrigerator at 36°F to 46°F (2°C to 8°C) in the original carton to protect from light. Do not freeze. Do not shake.

PRALUENT may be kept at room temperature up to 77°F (25°C) in the original carton for 30 days. If not used within the 30 days, discard PRALUENT.