Go through these in order and stop at the first one that applies. If you are reading this for someone else, answer for them.
Call emergency services if blistering occurs with trouble breathing, faintness, or swelling of the lips, tongue, or throat.
Emergency care is also appropriate after a significant chemical or electrical burn, or a large or deep heat burn.
Contact a healthcare professional promptly if you notice signs of infection, including increasing warmth, swelling, tenderness, pus, spreading redness, or fever.
Same-day assessment is also appropriate for painful vesicles on the forehead, nose, eyelid, or near an eye, particularly if you have eye redness or vision changes.
Seek urgent medical care for a rapidly spreading, painful blistering rash, especially when it involves the mouth, eyes, or genitals, or when skin is peeling.
This can occasionally represent a serious reaction or infection.
Arrange a routine appointment if the vesicles have no clear cause, keep returning, spread, or do not begin to heal.
You should also seek advice if they interfere with walking, sleep, work, or daily activities.
The article also says
Earlier assessment may be needed if the affected person is a newborn, has a weakened immune system, has poor circulation or reduced feeling in the area, or is seriously unwell.
Every sign above is quoted from the sofidex article on Vesicles. If you are not sure, err upward — it is always reasonable to be checked.