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Warning-sign checks

Transthyretin familial amyloid polyneuropathy: when to get help

Go through these in order and stop at the first one that applies. If you are reading this for someone else, answer for them.

  1. 1

    Is any of this happening now?

    Call 911

    Seek emergency help for severe breathing difficulty, chest pain, fainting with slow recovery, or signs of a stroke such as sudden facial weakness, arm weakness, or difficulty speaking.

    Emergency assessment is also appropriate for a serious injury after a fall or severe vomiting or diarrhea that leaves you unable to keep fluids down.

    And for anyone, someone who:

    • has sudden weakness or drooping on one side of the face or body, slurred speech, or sudden confusion
    Other emergency signs, for anyone
    • Someone who is struggling to breathe, gasping, choking, or cannot get words out
    • Someone who has chest pain, tightness or pressure lasting more than a few minutes
    • Someone who is unconscious, or cannot be woken
    • Someone who is bleeding heavily and it will not stop with firm pressure
    • Someone who has had a seizure that will not stop, or does not wake up afterwards
    • Someone who has lips or skin that look pale, blue, grey or blotchy
    • Someone who you believe has taken an overdose or swallowed something poisonous
  2. 2

    Is any of this happening?

    Be seen today

    Contact your care team promptly for a new foot wound, repeated falls, worsening ankle swelling, increasing breathlessness, new palpitations, reduced urine output, or difficulty eating and drinking.

    And for anyone, someone who:

    • has a new severe headache unlike any they have had before
  3. 3

    Does any of this apply?

    Book an appointment

    Arrange a routine appointment if you develop persistent numbness, burning pain, bowel changes, dizziness on standing, unexplained weight loss, or worsening balance.

    This is especially important if a relative has a known `TTR` variant or ATTR amyloidosis.

    These symptoms may need assessment before your next scheduled follow-up.

Every sign above is quoted from the sofidex article on Transthyretin familial amyloid polyneuropathy. If you are not sure, err upward — it is always reasonable to be checked.