Go through these in order and stop at the first one that applies. If you are reading this for someone else, answer for them.
Call emergency services for trouble breathing, swelling of the face or throat, or widespread hives after medicated iontophoresis.
These can be signs of a serious allergic reaction.
Stop treatment and contact your healthcare team promptly if you develop a persistent burn, blistering, worsening rash, increasing pain, or signs of skin infection such as spreading redness, warmth, swelling, or drainage.
Seek urgent medical care for fainting, a new irregular heartbeat, or severe dizziness during or after treatment.
Contact the team routinely if irritation keeps returning, sweating is not improving after the planned course, or you are unsure how to use home equipment safely.
Every sign above is quoted from the sofidex article on Iontophoresis. If you are not sure, err upward — it is always reasonable to be checked.