Go through these in order and stop at the first one that applies. If you are reading this for someone else, answer for them.
1
Is any of this happening now?
Call 911
Get urgent or emergency help for:
A finger or toe becoming black, severely painful, or persistently blue
Sudden weakness, facial drooping, speech difficulty, or confusion
Sudden loss of vision or a severe new visual disturbance
Chest pain, fainting, or severe shortness of breath
Coughing up blood
Severe abdominal pain, especially with vomiting or bloody stool
These symptoms may indicate blocked blood flow, major bleeding, or serious organ involvement.
Other emergency signs, for anyone
Someone who is struggling to breathe, gasping, choking, or cannot get words out
Someone who has chest pain, tightness or pressure lasting more than a few minutes
Someone who has sudden weakness or drooping on one side of the face or body, slurred speech, or sudden confusion
Someone who is unconscious, or cannot be woken
Someone who is bleeding heavily and it will not stop with firm pressure
Someone who has had a seizure that will not stop, or does not wake up afterwards
Someone who has lips or skin that look pale, blue, grey or blotchy
Someone who you believe has taken an overdose or swallowed something poisonous
2
Is any of this happening?
Be seen today
Seek prompt medical advice for blood or foam in your urine, new swelling, rapidly worsening numbness or weakness, painful skin sores, or a clear drop in urine output.
3
Does any of this apply?
Book an appointment
Arrange routine medical review if you develop repeated purple spots, unexplained joint pain, persistent tiredness, new numbness, or cold-related colour changes in your fingers or toes.
These symptoms have many possible causes and need appropriate assessment rather than self-diagnosis.
Every sign above is quoted from the sofidex article on Cryoglobulinemia. If you are not sure, err upward — it is always reasonable to be checked.