Go through these in order and stop at the first one that applies. If you are reading this for someone else, answer for them.
1
Is any of this happening now?
Call 911
These findings may need timely blood tests but are not always an emergency.
Seek emergency care for:
Severe difficulty breathing, chest pain, fainting, or confusion
Sudden weakness on one side, trouble speaking, or other possible stroke symptoms
Coughing up blood or sudden shortness of breath that could suggest a lung clot
A cold, painful body part that remains blue, very pale, or numb after gentle warming
Rapidly worsening weakness or symptoms of severe anemia
And for anyone, someone who:
has lips or skin that look pale, blue, grey or blotchy
Other emergency signs, for anyone
Someone who is struggling to breathe, gasping, choking, or cannot get words out
Someone who has chest pain, tightness or pressure lasting more than a few minutes
Someone who has sudden weakness or drooping on one side of the face or body, slurred speech, or sudden confusion
Someone who is unconscious, or cannot be woken
Someone who is bleeding heavily and it will not stop with firm pressure
Someone who has had a seizure that will not stop, or does not wake up afterwards
Someone who you believe has taken an overdose or swallowed something poisonous
2
Is any of this happening?
Be seen today
Contact the treating team promptly for worsening fatigue, new jaundice, dark urine, fever, increasing shortness of breath, or a clear change in cold-related symptoms.
3
Does any of this apply?
Book an appointment
Routine visits may include a review of fatigue, breathing, circulation symptoms, infections, and the effect of the condition on daily activities.
Blood tests may track hemoglobin, reticulocytes, bilirubin, LDH, and other signs of hemolysis.
The article also says
CAD is usually monitored by a hematologist.
People receiving treatment may need additional monitoring for infusion reactions, infections, treatment effectiveness, and medication-specific side effects.
Vaccination plans should be reviewed before complement-blocking therapy when possible.
Every sign above is quoted from the sofidex article on Cold agglutinin disease. If you are not sure, err upward — it is always reasonable to be checked.